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apalutamide will minimize the level or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medicines which are CYP2C19 substrates may lead to lower publicity to those remedies.iloperidone raises levels of diazepam by affecting hepat